玫瑰鲜花饼中四种阿维菌素类药物残留水平分析及慢性膳食风险评估
Analysis of Four Avermectin Drugs Residual Levels in Rose Flower Cakes and Chronic Dietary Risk Assessment
黄玉媛 1徐幸 2段吉燕 1张燕 2字杰军2
作者信息
- 1. 大理大学公共卫生学院,云南大理 671000
- 2. 大理州质量技术监督综合检测中心,云南大理 671000
- 折叠
摘要
为了解玫瑰鲜花饼中是否存在药物残留情况,以及是否存在慢性膳食摄入风险情况.本文通过检测玫瑰鲜花饼中四种阿维菌素类药物的残留情况,对其药物残留进行水平分析,评估其慢性膳食摄入风险.四种药物分别是阿维菌素、多拉菌素、乙酰氨基阿维菌素、伊维菌素.共收集了 43种玫瑰鲜花饼样品,采用优化的QuEChERS方法对样品进行前处理,并用高效液相色谱-串联质谱仪来测定这 4种化合物的残留水平,对它们进行慢性膳食摄入风险评估及风险排序.结果表明,四种阿维菌素类药物标线的判定系数均大于 0.99,检出限的范围为 0.1～0.7µg/kg,回收率范围为 94.97%～102.09%,四种目标化合物只有阿维菌素被检出,检出率是 79%,残留量范围为 1.89～4.58µg/kg.对四种药物进行食品安全指数分析(IFS),阿维菌素为 1.3×10-3、多拉菌素为 1.0×10-4、乙酰氨基阿维菌素为 1.7×10-6、伊维菌素为 1.2×10-5;对四种目标化合物进行风险评估,并进行风险排序,四种药物总分均低于 50,说明目前鲜花饼中阿维菌素类药物的残留水平不高,风险较低.建议将其纳入食用玫瑰种植过程中农药登记名单并制定相应限量标准.
Abstract
To understand whether there was a drug residue in the rose flower cake,and whether there was a risk of chronic dietary intake.In this paper,the residues of four avermectins in rose flower cake were detected,the residual levels of drug residues were analyzed,and the risk of chronic dietary intake was evaluated.The four drugs were avermectin,doramectin,acetylamineavermectin and ivermectin.A total of 43 rose flower cake samples were collected,and the optimized QuEChERS method was used to pre-treat the samples.The residue levels of the four compounds were determined by high performance liquid chromatography-tandem mass spectrometry,and their chronic dietary intake risk assessment and risk rank were performed.Results show that the four kinds of abamectin drugs line of correlation coefficient were greater than 0.99,the detection limit of the range of 0.1～0.7µg/kg,recovery range of 94.97%～102.09%.Only avermectin was detected in the 4 target compounds,the detection rate was 79%,and residual range of 1.89～4.58 µg/kg.The food safety index analysis(IFS)of the four drugs was 1.3×10-3 for avermectin,1.0×10-4 for doramectin,1.7×10-6 for acetylavermectin,and 1.2×10-5 for ivermectin.Risk assessment on four kinds of target compounds,and to the risk of ordering,total four drugs were less than 50.This indicated that the residual level of avermectins in rose flower cakes was not high at present,and the risk was low.It was suggested that it should be included in the registration list of pesticides and the corresponding limit standards should be established.
关键词
膳食摄入风险评估/阿维菌素类药物/农药残留/玫瑰鲜花饼Key words
risk assessment of dietary intake/avermectin drugs/pesticide residues/rose flower cakes引用本文复制引用
基金项目
云南省技术创新人才培养对象项目(202205AD160057)
出版年
2024
国家科技期刊平台
NSTL
万方数据