层次分析-熵权法评价结合正交试验优化铁皮石斛颗粒配方工艺
Optimization of Dendrobium officinale Granule Formula Process by Combining Analytic Hierarchy Process and Entropy Weight Method with Orthogonal Experiment
孙人杰 1田茂雨 1何琴 1吴德智 1陈唯实1
作者信息
- 1. 贵州中医药大学,贵州贵阳 550025
- 折叠
摘要
采用多指标综合评分法结合正交试验,优化铁皮石斛颗粒配方工艺.运用复杂系统熵聚类算法,对铁皮石斛保健品的注册信息进行分析,挖掘含铁皮石斛的保健品中原料药的配方组成;进一步以颗粒的成型率、溶化率、吸湿率、休止角为指标,筛选稀释剂,并以原料/稀释剂比例、乙醇体积浓度、乙醇用量为影响因素,采用层次分析法(analytic hierarchy process,AHP)结合熵权法(entropy weight method,EWM)确定综合权重,通过正交试验优化颗粒的配方工艺.结果表明,复杂系统熵聚类算法确定配方组合为铁皮石斛、枸杞、白芍;AHP-EWM法确定各指标权重分别为:成型率 0.3567、休止角 0.0847、溶化率 0.1778及吸湿率 0.3808;优化所得铁皮石斛-枸杞-白芍颗粒剂最佳工艺:原料药材浸膏粉、糊精和微晶纤维素的用量分别为 5、3.5、1.5 g(即比例为10∶7∶3)、乙醇体积浓度 50%、乙醇用量 5 mL.验证试验中颗粒的AHP-EWM综合评分为 93.63±1.65,与理论预测值接近,表明优选的颗粒剂配方工艺稳定可行,本研究为铁皮石斛的相关保健品开发提供了参考.
Abstract
Optimize the formula process of Dendrobium officinale granules using a multi index comprehensive scoring method combined with orthogonal experiments.Based on the registered Dendrobium officinale health food,the formula composition of raw materials in Dendrobium officinale health food was determined by using complex system entropy clustering algorithm.The diluent was filtered by the formation rate,dissolution rate and moisture absorption rate of granules.The ratio of raw materials and diluents,ethanol volume concentration,and ethanol dosage were taken as the inspection factors.The analytic hierarchy process(AHP)and entropy weight method(EWM)were combined to establish a multi-index comprehensive evaluation method(AHP-EWM method).The formulation process of granules was optimized through orthogonal experiments.The results showed that the formula combination was Dendrobium officinale,Lycium chinense Mill.,and Paeoniae Radix Alba by the complex system entropy clustering algorithm.The AHP-EWM method determines the weights of each indicator as follows:Molding rate 0.3567,angle of rest 0.0847,melting rate 0.1778,and moisture absorption rate 0.3808.The optimal molding process was the raw material extract powder,dextrin,and microcrystalline cellulose(10∶7∶3,m/m),50％ethanol volume concentration,and 5 mL ethanol dosage.The valieation test result showed that the AHP-EWM comprehensive score of the granules was 93.63±1.65,which was close to the theoretical prediction value.The optimized granules formulation process was stable and feasible.This study would provide a reference for the development of health products of Dendrobium officinale.
关键词
铁皮石斛/熵聚类算法/层次分析法/熵权法/正交试验/配方工艺Key words
Dendrobium officinale/entropy clustering algorithm/analytic hierarchy process/entropy weight method/orthogonal experiment/formula process引用本文复制引用
基金项目
贵州省高等学校中药民族药(苗药)新剂型新制剂工程研究中心项目(黔教技[2022]022)
贵州省高等学校教学内容和课程体系改革项目(2020097)
贵州中医药大学教学内容和课程体系改革项目(贵中医教学工合字202009号)
出版年
2024
国家科技期刊平台
NSTL
万方数据