摘要
玉米醇溶蛋白是玉米淀粉加工的主要副产物,价格低廉且容易获取.基于其独特的自组装特性,玉米醇溶蛋白可通过多种方式构建成纳米颗粒,进而对生物活性物质进行荷载和输送.纳米颗粒的制备方法包括反溶剂沉淀、pH循环、电喷雾和微流控等.这些制备方法都可合成响应各种环境刺激且性质稳定的玉米醇溶蛋白基纳米颗粒.本文综述了刺激响应型玉米醇溶蛋白基纳米颗粒的制备方法、响应类型和应用最新进展.这些纳米载体可对内源性(pH、酶和氧化还原)和外源性环境刺激(磁和光)做出响应,已被用于食品智能包装、纳米农药和纳米医学中生物活性物质的包封递送.然而,仅依靠单一刺激响应很难实现活性物质的作用最大化,多重刺激(双重刺激、三重刺激等)响应的纳米颗粒已成为递送领域的新发展趋势.未来,更多的研究应该投入到多刺激响应纳米颗粒的研发,以及如何将纳米颗粒的多重响应特性和纳米颗粒的靶向递送结合还有待进一步探索.
Abstract
Zein is a primary by-product of corn starch processing,which is inexpensive and easily obtainable.Based on its unique self-assembly properties,zein could be constructed into nanoparticles through various methods,enabling the loading and delivery of bioactive substances.The preparation methods of nanoparticles include anti-solvent precipitation,pH-driven,electrospray,and microfluidics.The preparation methods can produce zein-based nanoparticles that respond to various environmental stimuli and exhibit stable properties.This article reviews recent advances in the preparation methods,response types,and application progress of stimulus-responsive zein-based nanoparticles.The nanoparticles respond to endogenous(pH,enzymes,and redox)and exogenous environmental stimuli(magnetic and light),which have been used for encapsulated delivery of bioactive substances in smart packaging of food,nanopesticides,and nanomedicine.However,maximizing the effect of active substances is difficult to achieve by relying only on a single stimulus-response.Therefore,nanoparticles responding to multiple stimuli(double stimulation,triple stimulation,etc.)have become a new development trend in the delivery field.In the future,more research should be invested in developing multi-stimulus responsive nanoparticles,and how to combine the multiple response properties of nanoparticles with the targeted delivery of nanoparticles remains to be further explored.
基金项目
吉林省中青年科技创新创业卓越人才团队项目(创新类)(20210509026RQ)
国家科技期刊平台
NSTL
万方数据