萝卜硫素抗癌作用研究进展
Research Progress on Anticancer Effects of Sulforaphane
刘昕昕 1邹萍 2朱晨晨 2王洋 2王子铭1
作者信息
- 1. 温州大学生命与环境科学学院,浙江温州 325000
- 2. 东北林业大学生命科学学院,黑龙江哈尔滨 150040
- 折叠
摘要
癌症是威胁人类健康的头号杀手,其致死率占所有疾病之首.目前,治疗癌症的方式不可避免地存在相关副作用,因此开发安全、有效的抗癌药物成为人们关注的焦点.萝卜硫素作为十字花科植物中生物活性高的天然化合物之一,具有抗癌、抗氧化、抗病毒等特性,其中,治疗癌症的作用机理被人们广泛研究.萝卜硫素可以通过调控细胞周期、抑制细胞的迁移和侵袭以及抑制凋亡相关蛋白的表达从而抑制癌细胞的生长,也可以通过抗炎和抗氧化,抑制癌细胞的发生和发展.与传统治疗癌症的方法相比,萝卜硫素具有安全、易获得的特点,在抗癌方面有较大的发展潜力.本文综述了近两年萝卜硫素抗癌作用机制,为萝卜硫素的抗癌作用的进一步研究提供了相应的理论依据.
Abstract
Cancer is the leading cause of mortality in human health,with the highest mortality rate among all diseases.Unfortunately,most of the current cancer treatments inevitably come with certain side effects.Therefore,a significant amount of research is focused on the development of safe and effective anticancer drugs.Sulforaphane is one of the most bioactive natural compounds isolated from cruciferous plants.Numerous studies show its anti-cancer,antioxidant,and antiviral properties,as well as its anticancer mechanisms.Sulforaphane can inhibit the growth of cancer cells by regulating the cell cycle,inhibiting cell migration and invasion,and inhibiting the expression of apoptosis related proteins.It can also inhibit the occurrence and development of cancer cells through anti-inflammatory and antioxidant measures.Some reports also indicate that sulforaphane can impede the development of cancer cells through its anti-inflammatory and antioxidant effects.Compared to most traditional cancer treatment methods,sulforaphane is much safer and more reliable.It is also more readily available and has great anticancer potential.This paper review the anticancer mechanisms of sulforaphane over the past two years and provide the corresponding theoretical basis for further research on the anticancer effects of sulforaphane.
关键词
萝卜硫素/抗癌特性/抗炎/抗氧化/作用机制Key words
sulforaphane(SFN)/anti-cancer properties/anti-inflammatory/antioxidant/mechanism of action引用本文复制引用
基金项目
浙江省教育厅科技一般项目(Y202250066)
省自然科学基金-青年基金(LQ23C020001)
出版年
2024
国家科技期刊平台
NSTL
万方数据