基于DNA步行器的传感器技术在食品安全检测中的研究进展
Research Progress of Sensors Technology Based on DNA Walker in Food Safety Detection
宋思青 1司晓夏 1胡聚峰 1杜子沫 1陈历俊 1刘继超1
作者信息
- 1. 北京三元食品股份有限公司,国家母婴乳品健康工程技术研究中心,北京市乳品工程技术研究中心,母乳研究技术创新中心,北京 100163
- 折叠
摘要
随着DNA纳米技术的快速发展,各种结构和功能的DNA分子被用于构建具有动态行为的可编程纳米机器.其中,DNA步行器因其能够借助驱动力在预定轨道上自主、逐步移动以产生级联信号放大的优势,成为了生物传感、生物成像以及药物递送等领域日益增长的研究热点,在食品污染物快速超灵敏检测方面展现出巨大的应用潜力.本综述首先简要介绍了 DNA步行器的基本原理,并着重阐述了提升DNA步行器行走效率的策略,然后总结了其在食品安全检测中的应用,最后对DNA步行器未来研究方向进行了展望,为推动其实际应用提供了理论指导.
Abstract
With the rapid development of DNA nanotechnology,DNA molecules with various structures and functions are used to construct programmable nanomachines with dynamic behaviors.Thereinto,DNA walker possesses the advantages of the cascade signal amplification generated by the autonomous movement along the predetermined track by driving force,which is widely applied in the biosensing,biological imaging,and drug delivery fields,thus showing the great application potential for rapid and ultrasensitive detection of contaminants in food.This review first briefly introduces the basic principles of DNA walker,and describes the strategies for improving the efficiency of DNA walker in detail,then summarizes its applications in the food safety detection.Finally,the future research directions of DNA walkers are prospected to provide theoretical guidance for its real applications.
关键词
食品安全/DNA步行器/信号放大/核酸适配体/生物传感器Key words
food safety/DNA walker/signal amplification/nucleic acid aptamers/biosensors引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据