负载花色苷的抗酸性羧甲基壳聚糖凝胶微球的缓释研究
Sustained Release Properties of Acid Resistant Carboxymethyl Chitosan Gel Microspheres Loaded with Anthocyanins
李煦 1储若晴 1刘欣茹 1刘长霞 1叶霞 1范小振1
作者信息
- 1. 沧州师范学院化学与化工系,河北沧州 061000
- 折叠
摘要
为拓宽壳聚糖基水凝胶的应用范围,构筑可食用的花色苷(ACNs)递送体系,采用反相乳液法,以玉米油为连续相,水杨醛(SA)为交联剂,制备了具有抗酸性能的载ACNs羰甲基壳聚糖(CMCS)凝胶微球(ACNs/CMCS-SA),表征了其结构和形貌,研究了其稳定性、溶胀性能和缓释性能.结果表明,ACNs/CMCS-SA具有微米级粒径,表面光滑呈圆形;ACNs/CMCS-SA在酸性条件下稳定性良好,溶胀和缓释过程展现pH响应性;ACNs的释放行为符合Weibull模型,pH7和9时为扩散和骨架溶蚀复合释放机制控制,pH3和5时为菲克扩散和Case Ⅱ transport(0级-溶胀依赖性释放)联合释放机制控制.ACNs/CMCS-SA制备方法简单,过程绿色;对ACNs展现良好的胃酸保护和肠道释放性能,为环境友好型药物包封材料的开发和ACNs的应用提供了理论和实践参考.
Abstract
This study was aimed at broadening the application range of chitosan hydrogels and constructing an edible anthocyanins(ACNs)delivery system.The acid resistant carboxymethyl chitosan(CMCS)gel microspheres(ACNs/CMCS-SA)loaded with ACNs were prepared by inversion-phase emulsion method.During the process,corn oil was used as continuous phase and salicylaldehyde(SA)was used as crosslinking agent.The structure and morphology of ACNs/CMCS-SA were characterized.And the stability,swelling ability and sustained release properties were studied.The results showed that ACNs/CMCS-SA had a micron particle size with smooth and round surface.The gel microspheres showed good acid resistance and pH responsiveness during swelling and sustained release experiments.The sustained release behavior of ACNs conformed to Weibull model.In pH7 and pH9 media,the release process of ACNs was controlled by a combination mechanism of diffusion and skeleton dissolution.In pH3 and 5 media,it was controlled by a combination ofFick diffusion and Case Ⅱ transport(order 0 grade-swelling dependent release).The preparation method of ACNs/CMCS-SA was simple and green,and the sample exhibited good gastric acid protection and intestinal release performance for ACNs.Therefore,this study lays a theoretical and experimental foundation for the development of environmentally friendly drug encapsulation materials and the application of ACNs.
关键词
花色苷(ACNs)/释放性能/动力学/pH响应/反相乳液法/凝胶微球Key words
anthocyanins(ACNs)/release properties/dynamics/pH response/inversion-phase emulsion method/gel microsphere引用本文复制引用
基金项目
河北省高等学校科学研究项目(ZC2022044)
沧州师范学院2023年度大学生科技创新能力培育专项(DXSZDL2023002)
沧州师范学院科研创新团队资助(cxtd11901)
出版年
2024
国家科技期刊平台
NSTL
万方数据