膳食纤维缓解结肠炎作用机制研究进展
Advances in Understanding the Role Mechanism of Dietary Fiber in Mitigating Colitis
王勇 1李玥 1崔丽娴 2刘素稳 3何大柃 1常学东3
作者信息
- 1. 河北科技师范学院食品科技学院,河北秦皇岛 066004
- 2. 河北省农林科学院昌黎果树研究所,河北秦皇岛 066600
- 3. 河北科技师范学院食品科技学院,河北秦皇岛 066004;河北省燕山农业特色产业技术研究院,河北秦皇岛 066004
- 折叠
摘要
结肠炎是一种持续时间长、病因不明、反复发作的炎症性肠道疾病,通常伴随着肠道细胞损伤、肠道免疫及肠道菌群异常等症状.大量研究表明,膳食纤维作为一种益生元,其代谢产物可选择性地改善肠道菌群的组成,进而提高肠道短链脂肪酸的水平、降低炎症因子表达、增强肠道免疫屏障功能,从而改善机体的炎症反应.膳食纤维这种通过其代谢产物发挥抗炎的作用,为辅助治疗结肠炎提供了新的研究思路.本文概述了结肠炎的发病机制,膳食纤维及其代谢产物与肠道菌群、炎症因子、免疫细胞之间的作用机制,旨在为膳食纤维缓解结肠炎和开发功能性食品提供理论依据.
Abstract
Colitis is an inflammatory intestinal disease that lasts for a long time,has an unknown cause,and occurs repeatedly.It is usually accompanied by symptoms such as intestinal cell damage,intestinal immunity,and abnormal intestinal flora.Numerous studies have shown that dietary fiber,as a prebiotic,its metabolites can selectively improve the composition of the intestinal flora,which in turn improves the level of intestinal short-chain fatty acids,reduces the expression of inflammatory factors,and enhances the function of the intestinal immune barrier,thereby improving the inflammatory response of the organism.This anti-inflammatory effect of dietary fiber through its metabolites provides new research ideas to assist in the treatment of colitis.This paper outlines the pathogenesis of colitis,and the mechanism of interaction between dietary fiber and its metabolites with intestinal flora,inflammatory factors and immune cells,aiming to provide theoretical basis for the alleviation of colitis by dietary fiber and the development of functional foods.
关键词
膳食纤维/结肠炎/肠道菌群/免疫屏障/作用机制Key words
dietary fiber/colitis/intestinal microbiota/immune barrier/mechanism of action引用本文复制引用
基金项目
国家重点研发计划(2023YFD1600803)
河北省产业创新创业团队(215A7103D)
河北省重点研发计划(23317102D)
出版年
2024
国家科技期刊平台
NSTL
万方数据