In order to provide theoretical support for diabetes prevention and therapy,this study investigated the regulatory effect of Berberis dasystachya Maxim.Polysaccharide(BDP)on glucose and lipid metabolism in streptozotocin(STZ)-induced diabetic rats.Diabetic model rats were randomly assigned to the model control group,low-dose polysaccharide group(BDP-L,10 mg/kg),mid-dose polysaccharide group(BDP-M,200 mg/kg),and high-dose group(BDP-H,400 mg/kg).Blood lipid levels,lipid metabolic enzyme activity,and antioxidant enzyme activity served as evaluation markers.Results showed that after 28 days of administering yellow thorn polysaccharide,the BDP-treated groups exhibited significantly(P＜0.05)lower blood glucose and lipid levels compared to the model group,with a remarkable 39.16％reduction in blood glucose in the high-dose group(P＜0.01).In contrast,serum insulin levels and hepatic glycogen(HG)levels increased in the BDP-treated groups(P＜0.05 or P＜0.01),with a 1.28-fold increase in serum insulin(P＜0.01)and an 89.79％increase in HG(P＜0.01)in the high-dose group.Furthermore,compared to the model group,serum and pancreatic levels of catalase(CAT),superoxide dismutase(SOD),and reduced glutathione(GSH-Px)were significantly elevated(P＜0.05 or P＜0.01),while malondialdehyde(MDA)levels were considerably reduced(P＜0.05)in a dose-dependent manner following BDP treatment.In conclusion,BDP effectively improved glucolipid metabolism in diabetic rats by alleviating oxidative stress,ultimately safeguarding pancreatic β-cell integrity in type Ⅰ diabetes.
维普
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