基于肠-脑轴探讨植物多糖干预肠道菌群抗抑郁的研究进展
Exploring the Antidepressant Effects of Plant Polysaccharides on Gut Microbiota Based on the Gut-Brain Axis
蒋玉珍 1刘俊熙 1杨扬 1钟膳蔚 1黄安晴 1陈晓程 1杜冰 1黎攀1
作者信息
- 1. 华南农业大学食品学院,广东广州 510642
- 折叠
摘要
抑郁症是一种严重的情绪障碍疾病,患者通常表现出持续显著的悲伤情绪、意志消沉等临床特征.抑郁症发病机制复杂,近年肠-脑轴理论的研究为抑郁症探索提供可能的内在机制,体现在抑郁患者肠道菌群紊乱、高炎症水平和异常的神经递质水平等方面.植物多糖具有多种生物活性,研究发现其能够基于肠-脑轴调节肠道菌群不同代谢途径缓解抑郁,但其作用机理尚未得到系统的总结.因此,本文通过调研近年相关文献资料,从肠-脑轴的角度出发探讨植物多糖通过肠道菌群调节短链脂肪酸、脂多糖水平和色氨酸代谢等途径发挥抗抑郁作用,综述了不同植物多糖改善抑郁的机制和构效关系,为阐述植物多糖抗抑郁的机制及开发抗抑郁多糖资源提供理论依据.
Abstract
Depression is a severe emotional disorder characterized by persistent and prominent clinical symptoms,such as sadness and a loss of interest or pleasure.The pathogenesis of depression is intricate,and in recent years,investigations into the gut-brain axis theory have offered viable endogenous mechanisms for further exploration of depression.This theory is supported by evidence of disrupted gut microbiota,elevated inflammation markers,and deviant neurotransmitter levels in individuals with depression.Plant polysaccharides exhibit various biological activities and have been shown to modulate different metabolic pathways within the gut microbiota,thus impacting depression through the gut-brain axis.Nevertheless,a comprehensive summary of their mechanisms of action is currently lacking.Therefore,this study explores the potential antidepressant effects of plant polysaccharides by examining their regulation of short-chain fatty acids,lipopolysaccharides,and tryptophan metabolism within the gut microbiota and the gut-brain axis.Through a comprehensive analysis of recent literature,this article reviews the intricate relationships between various plant polysaccharides and their mechanisms in alleviating depression.It provides a theoretical basis for understanding how plant polysaccharides act as antidepressants and for developing resources for antidepressant polysaccharides.
关键词
多糖/肠-脑轴/肠道菌群/抑郁症/短链脂肪酸Key words
polysaccharide/gut-brain axis/gut microbiota/depression/short chain fatty acids引用本文复制引用
基金项目
国家自然科学基金青年基金(32202058)
广西药用资源保护与遗传改良重点实验室资助课题(KL2023KF03)
出版年
2024
国家科技期刊平台
NSTL
万方数据