摘要
多糖纳米硒(Polysaccharide nano-selenium,Polysaccharide-SeNPs)具有独特的性质和生物学功能,在医学、食品和制药等研究领域具有无限的潜力和应用前景.本文主要从多糖、纳米硒和多糖纳米硒的结构和性质出发,阐述多糖与纳米硒二者之间的互补组合关系,纳米硒借助多糖分支结构中的羟基在其表面形成氢键或Se-O键,以达到分散和稳定的作用.本文对多糖纳米硒制备条件、方法及优化方式进行总结.目前,常用化学合成法制备多糖纳米硒,利用超声波、真空、高压或酶等辅助技术提高其产率或生物学活性.其次,归纳了近5年在国际上已发表具有代表性生物学作用的多糖纳米硒.本文着重论述多糖纳米硒在医学、食品、药品及保健品等相关研究领域的应用和进展.多糖纳米硒的研究为中药多糖及中医药学等领域拓宽了新的思路,为进一步探索新兴且具备高效生物学作用"硒"形貌提供了有利的参考依据.
Abstract
Polysaccharide nano-selenium(polysaccharide selenium nanoparticles,Polysaccharide-SeNPs)exhibits unique properties and biological functions,offering limitless potential and promising applications in various fiels such as medicine,food and pharmacology.This review mainly focuses on the structure and properties of polysaccharides,nano-selenium(selenium nanoparticles,SeNPs)and the complementary combination of polysaccharides and SeNPs.SeNPs utilizes the hydrogen or Se-O bonds on its surface,thereby achieving dispersion and stability.The article provides a summary of the preparation conditions,methods,and optimization strategies for Polysaccharide-SeNPs.Currently,chemical synthesis methods are commonly used to produce Polysaccharide-SeNPs,with auxiliary techniques such as ultrasound,vacuum,high pressure,or enzymes employed to enhance yield or biological activity.Furthermore,the article reviews representative biological effects of Polysaccharide-SeNPs reported in the international literature over the past five years.Finally,emphasis is placed on the application and progress of Polysaccharide-SeNPs in the fields of medicine,food,pharmaceuticals,and health products.The study of Polysaccharide-SeNPs expands new perspectives in the field of traditional Chinese medicine,particularly polysaccharides derived from Chinese herbal medicine,providing a valuable reference for exploring novel and highly biologically active"selenium-shaped"entities.
基金项目
黑龙江省省属高等学校基本科研业务费科研项目(2022-KYYWF-0714)
黑龙江省中医药科研项目(ZHY2023-124)
牡丹江医学院研究生导师科研专项计划(YJSZX2022039)
黑龙江省大学生创新创业训练计划项目(202310229019)
维普
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