A This article focuses on the inhibition of a-amylase of the extracts from Momordica Charantia L, Gynostemma, yam, propolis. The results show that except the extracts of yam the rest of three natural products all have obvious effect on inhibiting α-amylase, and the 50% inhibiting concentration(IC50, mg/ mL)of each is 30.6, 40.7, 36.1 mg/mL which is 2.25, 1.69, 1.9 times than acarbose.