Comparative Study on Pharmacokinetics and Excretion Rate of Docosahexaenoic Acid in Bovine Milk between Exogenous and Endogenous Sources
Increasing dietary docosahexaenoic acid(DHA)intake of dairy cows would increase the DHA content in milk,and the endogenous DHA milk produced by dairy cows has better sensory quality than exogenous(added)DHA milk.The purpose of this study was to compare the differences in the absorption and excretion of DHA from two kinds of milk in the body.Male rats with SPF grade were selected as test animals and fed endogenous DHA milk,exogenous DHA milk and algal oil supplemented diets,respectively,and average intake of DHA were 6.75,11.25,200 mg/kg in each corresponding group.Serum and fecal samples were collected at 0,1,2,4,8,12,24 h after intake,and DHA content in the samples was detected.The pharmacokinetic parameters and excretion rate of DHA in rats were analyzed.The results showed that there were significant differences between the algal oil group and the DHA milk groups in terms of DHA peak time,peak concentration and area under the curve at drug time.The area under the curve of endogenous DHA milk was higher but not significant,than that of exogenous DHA milk,and the fecal DHA excretion rate was significantly lower than that of the latter.Therefore,the DHA absorption efficiency of endogenous DHA milk is higher than that of exogenous DHA milk.
万方数据
维普
