Micromeritics Properties and Direct Compression Process of Zinc-Rich Yeast
The article explored the micromeritics properties of zinc-rich yeast and evaluated the direct compression process.The particle size distribution and fluidity parameters of each type of zinc-rich yeast raw material were determined by the laser particle size distribution instrument and the intelligent powder characteristic tester respectively,and the hygroscopicity test was carried out.ZP-10A tablet machine was used to press different types of zinc-rich yeast raw materials,and the compressibility and molding of zinc-rich yeast raw materials were evaluated by weight difference,release force,disintegration time,brittle strength,tensile strength and other parameters and their change rules.According to the detection data of different types of zinc-rich yeast raw materials,the D50 value of zinc-rich yeast 10B and zinc-rich yeast deconucleotide type is mainly distributed in 48.56-60.50 μm,the particle size distribution is more uniform,and the moisture absorption rate is 8.84％,7.22％,which is weak in hygroscopic properties,and has good liquidity through the evaluation of liquidity parameters.During the tablet preparation,zinc-rich yeast 10B and zinc-rich yeast deconucleotide type,with lower release force,greater tensile strength and better molding,are more suitable for direct compression compared with other raw materials.This study explored the regulations of pressibility and formability of different models of zinc-rich yeast under different pressures,which can provide a theoretical basis for the application of zinc-rich yeast in solid preparations.
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