High Throughput Screening of 86 Chemical Factors in Food Packaging Paper by Ultra High Performance Liquid Chromatography Time-of-Flight Mass Spectrometry
A high throughput screening method for 86 chemical factors in food packaging paper was established based on ultra high performance liquid chromatography time-of-flight mass spectrometry.With the help of softwares Peak View,MasterView and Library View,a first-level accurate quality database and a second-level fragment mass spectrum database for 86 chemical factors were constructed.Samples were extracted by methanol and separated by T3 column,the acetonitrile and 0.1％formic acid aqueous solution were used as mobile phases for gradient elution.The data were collected by electrospray ion source with positive and negative ion scanning modes.By comparing precise mass number,retention time,isotope ratio and secondary fragments in the mass database,86 chemical factors in food packaging paper were quickly screened.This method had the advantages of simple sample pretreatment,accuracy,sensitivity,high throughput,and strong practicality,make it suitable for rapid screening of common chemical factor residues in food packaging paper.
food packaging paperultra performance liquid chromatography-time-of-flight mass spectrometrychemical factorshigh throughput
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