Preparation Process and Characterization of Allicin Nanoemulsions
Utilized a high-power ultrasonication emulsification technology to prepare nanoemulsion of Allicin,aiming improve its sensitivity to heat and alkaline conditions,as well as minimize the volatility of its pungent odor to enhance its stability,antibacterial properties,and optimize the preparation process.Taking the average particle size as the indicator,the process conditions were optimized by single factor tests and Box-Behnken response surface method,the optimal process parameters were determined as follows:tween-80 mass fraction of 1.30 wt％,Allicin mass fraction of 10 wt％,ultrasonic time of 15 min,ultrasonic power of 255 W,resulting in an average particle size of 223.27 nm.The centrifugal stability and antibacterial activity of Allicin nanoemulsions were evaluated.The results indicated excellent centrifugal stability of Allicin nanoemulsions,and superior inhibitory effects on Staphylococcus aureus compared to Escherichia coli.The study provides theoretical basis and technical references for the application of Allicin.
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