Effects of Soybean Peptides and Auricularia cornea Polysaccharides on Anti Fatigue and Gut Microbiota in Mice
The study investigated the combined effects of soybean peptides(SP)and Auricularia cornea polysaccharides(AP)on anti fatigue and gut microbiota in mice.The mice were randomly divided into four groups for a 4-week dietary intervention,namely the control group(CK group),SP group,AP group,and SP-AP group.The combined effects of SP and AP on the anti fatigue mechanism were analyzed by measuring serum biochemical indicators,antioxidant indicators,and energy metabolism related indicators.The results showed that the combined using of SP and AP significantly improved the exhaustion swimming time of mice.Compared with the CK group mice,the combined using of SP-AP significantly reduced the blood serum urea nitrogen(BUN),lactic acid(LA),and tumor necrosis factor(TNF-α)in exhausted swimming mice,significantly increased the levels of interleukin-6(IL-6),liver glycogen,and muscle glycogen.The combined use of SP-AP improves exercise fatigue by increasing the activity of superoxide dismutase(SOD),peroxidase(CAT),and glutathione peroxidase(GSH-Px)in the liver and muscle of mice,and reducing the level of malondialdehyde(MDA).In addition,the SP-AP combination group significantly increased the activities of Ca2+Mg2+-ATPase,succinate dehydrogenase(SDH),and pyruvate kinase(PK)in the liver and muscle of mice.In addition,the use of SP and/or AP significantly altered the gut microbiota composition of mice.In summary,the combined use of SP-AP can improve exercise fatigue in mice by reducing the accumulation of BUN and LA in serum,improving the body's antioxidant capacity,and regulating the body's energy metabolism process.This may also be related to changes in the gut microbiota composition of mice.This study provides a new approach for the development of anti fatigue functional foods.
万方数据
维普
