The study investigated the impact of flavonoids from agarwood leaves on lipid metabolism in HepG2 cells induced by oleic acid.Cell proliferation was assessed using the water-soluble tetrazolium salt method.Biochemical kits were employed to measure lipid metabolism-related factors levels within cells,including triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C).Additionally,oxidative stress-related factors levels such as reactive oxygen species(ROS),malondialdehyde(MDA),superoxide dismutase(SOD),glutathione(GSH),and catalase(CAT)were measured.The results showed that flavonoids from agarwood leaves reduced the levels of TG,TC,LDL-C,MDA,and ROS released in oleic acid-induced HepG2 cells,promoted the release of HDL-C,and increased the activities of SOD,GSH,and CAT.Agarwood leaf flavonoids can alleviate oleic acid-induced lipid metabolism disorders in HepG2 cells,its effect may be related to the regulation of cellular lipid metabolism,scavenging of reactive oxygen species,and enhancement of antioxidant enzyme activity.
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