Effect of Flavonoids from Agarwood Leaves on Lipid Metabolism in HepG2 Cells Induced by Oleic Acids
The study investigated the impact of flavonoids from agarwood leaves on lipid metabolism in HepG2 cells induced by oleic acid.Cell proliferation was assessed using the water-soluble tetrazolium salt method.Biochemical kits were employed to measure lipid metabolism-related factors levels within cells,including triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C).Additionally,oxidative stress-related factors levels such as reactive oxygen species(ROS),malondialdehyde(MDA),superoxide dismutase(SOD),glutathione(GSH),and catalase(CAT)were measured.The results showed that flavonoids from agarwood leaves reduced the levels of TG,TC,LDL-C,MDA,and ROS released in oleic acid-induced HepG2 cells,promoted the release of HDL-C,and increased the activities of SOD,GSH,and CAT.Agarwood leaf flavonoids can alleviate oleic acid-induced lipid metabolism disorders in HepG2 cells,its effect may be related to the regulation of cellular lipid metabolism,scavenging of reactive oxygen species,and enhancement of antioxidant enzyme activity.
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