Stability and Hypoglycemic Effect of Camellia Seed Cake Peptides
The gastrointestinal digestion,temperature,and pH stablility of two peptides,LLVLYYEY(CSCPs-1)and LLLLPSYSEF(CSCPs-2),identified from Camellia seed cake peptides(CSCPs)with hypoglycemic activity were evaluated in vitro.The hypoglycemic effect of zebrafish was evaluated by the hyperglycemic model and the mechanism of hypoglycemic action was preliminarily explored.The results showed that the activities of CSCPs-1 and CSCPs-2 did not change significantly during gastric digestion,but significantly decreased during intestinal digestion,showing good acid-base stability and thermal stability.Compared with the high glucose model group,the low,medium,and high dose groups of CSCPs-1 and CSCPs-2 could significantly reduce the blood glucose level in zebrafish and improve the mRNA abnormal expression of Insulin,Pck1,and Pdx-1,the key factors of glucose metabolism caused by high glucose.This study indicated that Camellia hypoglycemic peptides CSCPs-1 and CSCPs-2 have the potential to be developed into anti-diabetic functional foods.
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