Optimization of Ultrasound-Assisted Extraction of Proanthocyanidins from Perilla frutescens Using Response Surface Methodology
The ultrasound-assisted extraction of proanthocyanidins from defatted seed meal of Perilla frutescens was optimized in the present work.The effects of solid-to-liquid ratio,ethanol concentration,ultrasound power,temperature and extraction time on the extraction yield of proanthocyanidins were evaluated.Main influencing factors were selected based on the results of single factor experiments and optimized using response surface methodology according to the principle of BoxBehnken design.The optimal extraction conditions were determined as follows:extraction with a 15-fold volume of 70％ aqueous ethanol solution at 70 ℃ with an ultrasound power of 100 W for 0.5 h.Under these conditions,the theoretically predicted yield ofprocyanidins was 0.232％,and the actually measured value was 0.229％.
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