Optimization of Antroquinonol Production in Solid-State Fermentation of Antrodia camphorata Using Response Surface Methodology
In this study, response surface methodology based on Box-Behnken design was used to optimize the culture conditions for the production of the bioactive metabolite antroquinonol in solid-state fermentation of Antrodia camphorata.The optimal culture conditions were determined as inoculum amount of 296.80 mg/kg, Triton X-100 concentration of 1.10 mL/kg and coenzyme Q0 concentration of 0.23 g/kg.Under these conditions, the maximum predicted yield of antroquinonol was 865.85 mg/kg, which was in good agreement with the experimental value of 865.32 mg/kg.Therefore, the established model could be used for predicting the culture conditions of Antrodia camphorate for antroquinonol production.After optimization, the yield of antroquinonol was increased 232.09％ when compared with the control (260.57 mg/kg).
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维普
