Optimization of Synthesis Process and Characterization of Sodium Ferric Gluconate Complex
By monitoring the synthetic reaction of sodium ferric gluconate complex,pH value was found to have a significant impact on the iron content and yield of product.Under controlled pH conditions,specific production rate,iron content and yield of sodium ferric gluconate complex were investigated.The maximum iron content of 29.9％ and the maximum yield of 129.12％ were obtained when the reaction proceeded for 2 h with pH controlled at 11.0.Meanwhile,a 58.77％ reduction in the particle size of sodium ferric gluconate complex as well as a 33.33％ decrease in reaction time was found compared to that without pH control.Comparative analysis revealed that the synthetic reaction of sodium gluconate iron complex was a process involving complexation,separation and re-aggregation.The results of characterization confirmed the product under controlled pH condition to be sodium ferric gluconate complex with no change in iron-chelating capacity.Therefore,it has been found that pH control provides an effective and applicable approach towards the optimization of the preparation process of sodium ferric gluconate complex for achieving high yield and iron content simultaneously.
sodium ferric gluconate complexpH controlreaction processspecific production rateoptimization
国家科技期刊平台
NSTL
万方数据
维普
