Hypolipemic Effect of Acidic Polysaccharides from Auricularia auricula on Hyperlipidemia Mice
Objective:To explore the lipid-lowering effect of acidic polysaccharides from Auricularia auricula in hyperlipidemia mice.Methods:Acidic polysaccharides from Auricularia at different doses were intragastrically given to hyperlipidemic model mice to explore their effects on blood lipids and related enzymes.Results:Compared with the model group,the body weight of the treated mice decreased obviously,liver index and atherosclerosis index (AI) as well as serum TC and TG levels similarly declined obviously,whereas HDL-C levels increased significantly (P ＜ 0.01 or 0.05).Moreover,total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities in the middle and high dose treatment groups were significantly higher than those in the model group (P ＜ 0.01).Conclusion:Acidic polysaccharides from Auricularia auricula can significantly reduce blood lipid levels,fat accumulation in liver and artery atherosclerosis caused by excessive lipid intake in hyperlipidemia mice and protect against lipid peroxidation damage caused by hyperlipidemia.
acidic polysaccharides from Auricularia auriculablood fathypolipemic effect
国家科技期刊平台
NSTL
万方数据
维普
