魔芋葡甘聚糖和壳聚糖-富里酸纳米颗粒组成的pH值响应性水凝胶的制备
Fabrication of pH-Responsive Hydrogels Composed of Chitosan-Fulvic Acid Microparticles and Konjac Glucomannan
陈晓涵 1庞杰2
作者信息
- 1. 福建农林大学食品科学学院,福建福州 350002;教育部福建-台湾特殊海洋食品加工与营养工程研究中心,福建福州 350002
- 2. 福建农林大学食品科学学院,福建福州 350002;教育部福建-台湾特殊海洋食品加工与营养工程研究中心,福建福州 350002;肉制品食品安全技术国家重点实验室,福建厦门 361100;福建农林大学海洋学研究所,福建省海洋生物技术重点实验室,福建福州 350002
- 折叠
摘要
以壳聚糖-富里酸微粒子(chitosan-fulvic acid microparticles,CFMPs)为增强剂,制备一系列魔芋葡甘露聚糖(konjac glucomannan,KGM)水凝胶.CFMPs具有较高的表面位密度和含氧官能团,可诱导KGM与CFMPs之间形成氢键相互作用,形成更加致密的网络结构.研究CFMPs对KGM水凝胶网络结构和释放行为的影响.流变学结果表明,各成胶液稳定剪切黏度和动态黏弹性的规律性变化是由于网络结构的加强和较强的相互作用.傅里叶变换红外光谱分析结果证实,CFMPs的羧基(--COOH)与KGM聚合物链上的羟基(--OH)成功形成氢键.扫描电镜图像显示其结构致密,孔隙相互连通.另外,研究了氧氟沙星对KGM/CFMPs水凝胶在人工肠液和人工胃液作用下的体外释药行为.KGM/CFMPs水凝胶由于含质子化胺基团(-NH3+),具有良好的pH值响应性.这些结果表明,KGM/CFMPs水凝胶具有pH值响应性给药系统的潜力.
Abstract
A series of konjac glucomannan (KGM) hydrogels were prepared using chitosan-fulvic acid microparticles(CFMPs) as the reinforcing agents.CFMPs possessed high surface density and oxygen-containing functional groups,which could induce hydrogen-bonding interaction between KGM and CFMPs to form a more dense network structure.The effects of CFMPs on the network structure and releaseing behavior of KGM hydrogels were evaluated.The rheological results revealed that the regular change in the steady shear viscosity and dynamic viscoelasticity of all hydrogel-forming solutions was attributed to the reinforced network structure with strong interaction.Fourier transform infrared spectral analysis indicated that the carboxyl groups (-COOH) in CFMPs successfully formed hydrogen bonds with the hydroxyl groups (-OH) in the KGM polymer chains.Scanning electron microscopic images revealed that the structure of hydrogels was dense with interconnected pores.In addition,the in vitro drug-releasing behavior of KGM/CFMP hydrogels in artificial intestinal and gastric fluids was investigated.KGM/CFMP composite hydrogels possessed excellent pH-responsive property due to the protonated amine groups (-NH3+).Therefore,KGM/CFMP composite hydrogels have a huge potential as a pH-responsive drug delivery system.
关键词
魔芋葡甘聚糖/壳聚糖-富里酸纳米颗粒/水凝胶/pH值响应性释药Key words
konjac glucomannan/chitosan-fulvic microparticles/hydrogel/pH-controlled release引用本文复制引用
基金项目
出版年
2021
国家科技期刊平台
NSTL
维普
万方数据