类胡萝卜素和脂溶性维生素(carotenoids and fat-soluble vitamin,C&FSV)属于对机体健康有重要作用的高度亲脂性食品成分,主要通过外源性食物摄取.关于C&FSV的肠道吸收机制的认识已由最初的部分C&FSV通过简单扩散吸收发展到膳食C&FSV由特异转运蛋白介导吸收的新阶段.本文综述了C&FSV消化和吸收过程,重点关注转运蛋白介导下的肠细胞顶端转运、胞浆转运和细胞内代谢、肠细胞基底外侧膜分泌整个吸收过程的最新研究进展,同时对于C&FSV转运蛋白的调控进行了全面汇总,以期推动脂溶性活性物的肠道吸收机制研究进展,更好地发挥其健康效应.
Research Progress in Intestinal Absorption Mechanism of Dietary Carotenoids and Fat-Soluble Vitamins:Focus on Transporters
Carotenoids and fat-soluble vitamins(C&FSV)belong to the group of highly lipophilic food components that have important effects on the body's health,which are ingested mainly through consumption of foods.The knowledge about the intestinal absorption mechanism of dietary C&FSV has been developed from partial C&FSV absorption through simple diffusion to specific transporter-mediated absorption of dietary C&FSV.This paper reviews the latest research progress in the process of digestion and absorption of C&FSV with special focus on,transporter-mediated apical transport,cytosolic transport and intracellular metabolism in enterocytes,and secretion from the basolateral membrane of enterocytes for the entire absorption process,and it provides a comprehensive summary of the regulation of C&FSV transporters.This review is expected to drive the understanding of the intestinal absorption mechanism of lipid-soluble bioactives so that they can better exert their beneficial health effects.
国家科技期刊平台
NSTL
万方数据
维普
