Anti-aging Effect of Inactivated Bacillus sp.DU-106 in Caenorhabditis elegans
The aim of this study was to investigate the antioxidant and anti-aging effects and underlying mechanisms of inactivated Bacillus sp.DU-106 in Caenorhabditis elegans.The antioxidant activity of inactivated Bacillus sp.DU-106 was evaluated by in vitro free radical scavenging assay.The effects of inactivated Bacillus sp.DU-106 at various concentrations on the lifespan,stress response and antioxidant capacity of C.elegans were observed.The results illustrated that inactivated Bacillus sp.DU-106 possessed strong free radical scavenging capacity in vitro,meanwhile,inactivated Bacillus sp.DU-106 effectively extended the lifespan of C.elegans and improved its movement and stress resistance.Different concentrations of inactivated Bacillus sp.DU-106 increased the levels of catalase(CAT),superoxide dismutase(SOD)and glutathione in a dose-dependent manner.Fluorescence microscopy showed that treatment with inactivated Bacillus sp.DU-106 significantly reduced lipofuscin levels in C.elegans.In conclusion,inactivated Bacillus sp.DU-106 can exert an anti-aging effect perhaps by reducing lipofuscin accumulation and increasing the levels of antioxidant enzymes in C.elegans.This study provides a powerful basis for the development of Bacillus for application in nutraceuticals.
国家科技期刊平台
NSTL
万方数据
维普
