Electrochemical Sensor Based on Carboxymethyl Cellulose-Coated Copper Nanoparticle Composite for Detection of Norfloxacin in Milk
A highly sensitive electrochemical sensor for the detection of norfloxacin(NFX)was constructed using CMC@Cu/CB composites,which were prepared from carboxymethyl cellulose(CMC)-coated copper nanoparticles(Cu NPs)and carbon black(CB).The structure and morphology of CMC@Cu/CB were characterized by scanning electron microscope(SEM),X-ray photoelectron spectroscopy(SPS),and X-ray diffraction(XRD).The CMC@Cu/CB/GCE sensor was prepared by drop-casting the composite suspension on the glassy carbon electrode(GCE)surface.The results showed that the CMC@Cu/CB/GCE sensor,which was in the form of uniformly dispersed spheres,had a good current response to NFX,with a linear range of 0.4-100.0 μmol/L and a limit of detection(LOD)of 0.24 μmol/L(RSN=3).In addition,the modified electrode had good sensitivity and stability for the detection of NFX in real samples,and the spiked recoveries of NFX in milk extracts ranged from 98.8％-112.5％.Furthermore,thanks to the low price of raw materials used in the experimental process and the preparation extremely of low cost of the sensor,it is promising for actual applications.
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