短链脂肪酸介导的肠骨轴在骨代谢中的研究进展
Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism
张萱 1杨雪 1李新科 1孟璐 1王加启 1郑楠1
作者信息
- 1. 中国农业科学院北京畜牧兽医研究所,农业农村部奶及奶制品质量安全控制重点实验室,北京 100193;中国农业科学院北京畜牧兽医研究所,农业农村部奶产品质量安全风险评估实验室(北京),北京 100193
- 折叠
摘要
随着全球老龄化加剧,骨质疏松症等与年龄相关的骨骼代谢疾病发病率不断上升,寻求安全有效的治疗干预方法至关重要.目前肠道微生物及其代谢产物调节骨代谢已成为研究的热点.短链脂肪酸(short-chain fatty acids,SCFAs)如乙酸、丙酸和丁酸等,能够通过肠-骨轴发挥骨形成和骨吸收的调节作用,对骨稳态调节具有一定的积极作用,并能改善炎症性骨丢失.本文综述SCFAs通过内分泌、免疫、改善营养吸收等途径调控骨代谢稳态,以期为老年代谢性骨病的预防和治疗提供科学依据.
Abstract
As global aging intensifies,the incidence of age-related bone metabolic disorders,such as osteoporosis,continues to climb.Seeking safe and effective therapeutic interventions is of utmost importance.The modulation of bone metabolism by the gut microbiota and their metabolites has emerged as a focal area of research.Short-chain fatty acids(SCFAs),including acetic,propionic,and butyric acids,exert regulatory effects on bone formation and resorption through the gut-bone axis.Furthermore,SCFAs play positive roles in maintaining bone homeostasis and contribute to the alleviation of inflammatory bone loss.This review synthesizes the current knowledge about the mechanism by which SCFAs regulate bone metabolic homeostasis via endocrine pathways,immune modulation,and enhanced nutrient absorption,hoping to provide a scientific foundation for the prevention and treatment of metabolic bone diseases in the elderly.
关键词
肠-骨轴/短链脂肪酸/肠道微生物/骨代谢/骨质疏松症Key words
gut-bone axis/short-chain fatty acids/intestinal microbes/bone metabolism/osteoporosis引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据