Advances in metabolic engineering of Escherichia coli for producing aromatic compounds
Aromatic compounds are widely used in chemical,food and pharmaceutical fields,and most of them are obtained from the chemical synthesis or extraction of natural products.Natural microbes also has the ability to synthesize aromatic compounds in order to maintain their metabolic demands of life activities,but their capabilities of accumulation are very low.In recent years,metabolic engineering is applied to optimize,design and modify microorganisms,especially Escherichia coli,to increase the fermentation yield of aromatic compounds,which has achieved remarkable success and produce a variety of valuable aromatic derivatives.These advances are very important for utilizing renewable resources to solve the fossil energy crisis and difficulties in natural product extraction and other issues if the technologies of synthetic biology and cell factory become more prevalent in the future.
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