Soy protein isolate and maltodextrin were used as wall material and algae oil microcapsule was prepared by spray-drying.The formula investigated by single factor and optimized by orthogonal array design were as followings:the soy protein isolates and maltodextrin ratio 1∶2,the solid content in the wall material 15%,the suitable proportion of core material and wall material 1 ∶ 2,the ratio of fatty acid monoglyceride and sucrose fatty acid ester 3 ∶7 and the amount was 3%,The optimum spray drying conditions were:the inlet temperature 170 ℃,and outlet temperature 70 ℃,the pressure of homogeneous 45 MP.Under these conditions,the capsulation efficiency was 91.2%.The algae oil microcapsules produced under the optimal conditions had good sensory quality,solubility and oxidative stability with low water content.