Salmonella enterica serovar Typhimurium is the most common foodborne pathogen,posing a serious threat to public health due to the antibiotic resistance.Recent studies have shown that interference with the quorum sensing(QS)system on pathogens is one of the effective strategies to release their antibiotic resistance.QS is a cell communication mechanism that involves a variety of metabolic ac-tivities,such as biofilm formation,motility,virulence factors,adhesion and invasion.In order to systematically summarize the QS mecha-nisms of S.Typhimurium and its corresponding interference strategies,we firstly introduced five QS systems mediated by N-acyl-homo-serine lactones(AHL),autoinducer-2(AI-2),autoinducer-3(AI-3),indole and diffusible signaling factor(DSF).Then,we summa-rized the inhibition and promotion strategies of different QS systems from three aspects:signal molecule synthesis,extracellular transport &reaction,and interaction with receptors.Finally,we pointed out that the future development of QS interference strategies should be based on multi-target and multi-level system networks,which contributes better to solve the infection and the antibiotic resistance of Salmonella.
关键词
群体感应干扰/群体感应猝灭/肠道致病菌/抗生素耐药性/生物被膜/毒力因子
Key words
quorum sensing interference/quorum quenching/foodborne pathogen/antibiotic resistance/biofilm/virulence factors
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