Uncertainty evaluation for the determination of four quinolone residues in honey by liquid chromatography-tandem mass spectrometry
Objective:This study aimed to evaluate the determination uncertainty of four quinolones residues in honey by liquid chromatography-tandem mass spectrometry(LC-MS/MS).Methods:Based on GB 31657.2-2021,a mathematical model for sources of uncertainty evaluation was established.The uncertainty of each variable which affect the result were calculated and the weight of each uncertainty component was assessed.Results:The uncertainties in the determination of enrofloxacin,sarafloxacin,ofloxacin and ciprofloxacin in honey were(4.97±0.81),(10.13±1.58),(7.67±1.23),(14.97± 2.25)μg/kg(P=95％,k=2)respectively.Conclusion:The main influencing factors of the determination uncertainty were preparation and dilution process of standard solution and fitting of standard curve,which should be controlled in practical work.
uncertaintyliquid chromatography-tandem mass spectrometry(LC-MS/MS)enrofloxacinsarafloxacinofloxacinciprofloxacinhoney
万方数据
维普
