氧化玉米淀粉/明胶复合胶囊壳的制备与表征
Preparation and characterization of oxidized corn starch/gelatin composite capsules
谭心 1梁春艳 1邓松林 2陈启杰 1罗永清3
作者信息
- 1. 长沙理工大学化学化工学院,湖南长沙 410076
- 2. 湖南工业职业技术学院机械工程学院,湖南长沙 410000
- 3. 岳阳天添胶囊股份有限公司,湖南岳阳 414000
- 折叠
摘要
目的:采用改性淀粉与明胶共混制备胶囊壳,降低胶囊壳制备成本.方法:以玉米原淀粉为原料,采用15％用量的过氧化氢氧化制备氧化玉米淀粉,与明胶共混,分别通过流延法和浸渍法制备了氧化玉米淀粉/明胶复合胶囊膜和胶囊壳,并采用傅里叶变换红外光谱(FT-IR)、X射线衍射(XRD)、扫描电子显微镜(SEM)对其进行表征.结果:当氧化玉米淀粉与明胶质量比为5∶5,制备的氧化玉米淀粉/明胶复合胶囊壳的干燥失重在13.0％～15.0％,在蒸馏水和模拟人工胃液中的崩解时限在10 min以内,脆碎度不超过5粒.结论:采用氧化玉米淀粉与明胶共混制备的复合胶囊壳性能符合《中国药典》(2020)要求.
Abstract
Objective:Modified starch was used to mix with gelatin to prepare the capsule shell,and the cost of preparing the capsule shell was reduced.Methods:Oxidized corn starch prepared by using 15％hydrogen peroxide was used as raw material to mix with part of gelatin.The oxidized corn starch/gelatin composite film and capsules were prepared by casting method and impregnation method,respectively,and were characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD)and Scanning electron microscopy(SEM).Results:The results showed that the ratio of oxidized corn starch and gelatin was 5∶5,the drying weight loss of oxidized corn starch/gelatin composite capsules was 13.0％～15.0％,the disintegration time in distilled water and simulated artificial gastric juice was less than 10min,and the crunchability was not more than 5 granules.Conclusion:The properties of the composite capsule prepared by blending oxidized corn starch with gelatin met the requirements of Chinese Pharmacopoeia(2020).
关键词
氧化玉米淀粉/明胶/胶囊壳/制备/表征Key words
oxidized corn starch/gelatin/capsules/preparation/characterization引用本文复制引用
基金项目
国家级大学生创新训练项目(S202310536039)
出版年
2024
国家科技期刊平台
NSTL
万方数据