Preparation and characterization of oxidized corn starch/gelatin composite capsules
Objective:Modified starch was used to mix with gelatin to prepare the capsule shell,and the cost of preparing the capsule shell was reduced.Methods:Oxidized corn starch prepared by using 15％hydrogen peroxide was used as raw material to mix with part of gelatin.The oxidized corn starch/gelatin composite film and capsules were prepared by casting method and impregnation method,respectively,and were characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD)and Scanning electron microscopy(SEM).Results:The results showed that the ratio of oxidized corn starch and gelatin was 5∶5,the drying weight loss of oxidized corn starch/gelatin composite capsules was 13.0％～15.0％,the disintegration time in distilled water and simulated artificial gastric juice was less than 10min,and the crunchability was not more than 5 granules.Conclusion:The properties of the composite capsule prepared by blending oxidized corn starch with gelatin met the requirements of Chinese Pharmacopoeia(2020).
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