To study the antitumor activity in vivo of Spirulina polysaccharide. Spirulina polysaccharide was extracted with double enzyme hydrolysis. H22 tumor bearing mice were established entity and treated by gavage with 1 000 mg/kg/d of the polysaccharide. The tumor weight, tumor inhibition rate, thymus index and Spleen index, lymphocyte proliferation, kill rate of NK cells, detection of phagocytic, the concentrations of TNF-αand IFN-γin mice blood serum were measured to study antitumor function in vivo. The tumor inhibition rate was 74.53%, The thymus index and Spleen index, lymphocyte proliferation, kill rate of NK cells were raised, and the concentrations of TNF-αand IFN-γ in mice blood serum were increased. The Spirulina polysaccharide had played an important role in protecting the immune system and promoting the immune function of tumor bearing mice.
NETL
NSTL
维普
万方数据
