This study investigated the potential benefits of ocimene,an aromatic compound predominantly present in tobacco,basil essential oil,and lavender essential oil,in mitigating the effect of ultraviolet B(UVB)-induced photoaging in HaCaT keratinocytes and Hs68 fibroblasts.The photoaging-mitigating effect of ocimene in epidermal HaCaT cells was assessed by measuring oxidative stress damage markers and matrix me-talloproteinase(MMP)expression levels.The photoaging-mitigating effect of ocimene in dermal Hs68 cells was evaluated by measuring the secretion of MMP and the composition of the extracellular matrix.The results showed that in UVB-exposed epidermal HaCaT cells,ocimene effectively reduced the accumulation of reactive oxygen species and malondialdehyde but increased the activity of superoxide dismutase.The photoaging-in-duced oxidative stress was thus alleviated.Moreover,ocimene restrained the rise of UVB-induced MMP ex-pression levels.In UVB-exposed dermal Hs68 cells,ocimene exerted a protective effect on the extracellular matrix by inhibiting MMP expression and promoting collagen and hyaluronic acid secretion,indicating its pro-tective effect on skin photoaging.
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