Research progress on concomitant drugs affecting the efficacy of tumor immune checkpoint inhibitors
At present,the application of immune checkpoint inhibitors has been carried out in various tumors and has be-come a research hotspot.This study summarizes the concomitant drug studies affecting the efficacy of immune checkpoint inhibitors at home and abroad,and provides a reference for clinical practice.Taking"immune checkpoint inhibitors","tumors","efficacy","concomitant medications"and"complications"as keywords,the relevant literature of PubMed and CNKI journals from January 1st,2017 to June 30th,2023 was searched,and the inclusion criteria were:(1)the effect of concomitant medication on the efficacy of tumor immune checkpoint inhibitors;(2)the effect of concomitant medication on the complications of tumor immune checkpoint inhibitors;(3)The effect of concomitant medication on the prognosis of tumor immune checkpoint inhibitors.Exclusion criteria:(1)duplicate published or translated literature;(2)low-quality literature;(3)secondary literature of works and compilations and reviews.Finally,62 articles were included.The results showed that glucocorticoids,antibiotics,proton pump inhibitors,nonsteroidal anti-inflammatory drugs,metformin,an-tithrombotic drugs,opioids,statins,and β receptor blockers all affected the efficacy of immune checkpoint inhibitors to varying degrees.Antibiotics,proton-pump inhibitors,and opioids were thought to affect the prognosis of users of im-mune checkpoint inhibitors directly or indirectly through their gut microbiota,and were associated with poorer clinical outcomes.For nonsteroidal anti-inflammatory drugs,glucocorticoids,and antithrombotic drugs,the current research conclusions were not uniform.Statins,metformin,and β blockers have been suggested to be associated with improved clinical outcomes,but this needs to be further researched.It is suggested that many drugs commonly used in clinical prac-tice can affect the efficacy and complications of immune checkpoint inhibitors to varying degrees,which need to be paid clinical attention.However,most of the current studies are retrospective studies with small samples,and the effect of concomitant drugs on the efficacy of tumor immune checkpoint inhibitors still needs to be verified by large-sample,multi-center prospective studies.
immune checkpoint inhibitorstumorefficacycomplicationconcomitant medicationreview literature
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