Analysis of virus spectrum and epidemiological characteristics of 3 916 children with respiratory tract infection in Zibo
Objective To analyze the virus spectrum and epidemiological characteristics of respiratory tract infections in children at a tertiary hospital in Zibo,in order to provide a basis for the prevention and control of respiratory tract infec-tions in children in this area.Methods Throat swab samples of outpatient and inpatient 3 916 children under 14 years old with respiratory tract infection who visited the Zibo First Hospital from January 1,2020 to May 31,2023 were collected.Real-time fluorescent quantitative PCR was used to detect Epstein-Barr virus(EB),cytomegalo virus(CMV),influenza A virus(IFV-A),influenza B virus(IFV-B)and respiratory syncytial virus(RSV)for analyzing the virus spectrum and epidemiological characteristics.The data were analyzed by SPSS23.0 software,and the chi square test(x2)was used for inspection.Results Among the 3 916 children,the total positive rate of respiratory virus was 26.20％(1 026/3 916),of which the positive rates of IFV-A and RSV were higher,at 12.46％and 8.61％respectively.EBV had the highest posi-tive rate among school-aged children,at 3.06％,and there was statistical significance in the positive rate among children of different age groups,x2=12.747,P=0.005;CMV had the highest positive rate among infants,at 1.50％,and there was statistical significance in the positive rate among children of different age groups,x2=25.152,P＜0.001;IFV-A had the highest positive rate among school-aged children,at 21.78％,and there was statistical significance in the positive rate among children of different age groups,x2=146.817,P＜0.001;RSV had the highest positive rate among infants,at 31.33％,and the positive rate was statistically significant among children of different age groups,x2=342.591,P＜0.001.EBV had the highest positive rate among children in summer,at 3.32％,and there was statistical significance in the positive rate among children in different seasons,x2=10.220,P=0.017;IFV-A had the highest positive rate among children in spring,at 30.92％,and there was statistical significance in the positive rate among children in different sea-sons,x2=548.938,P＜0.001;IFV-B had the highest positive rate among children in winter,at 11.84％,and there was statistical significance in the positive rate among children in different seasons,x2=278.341,P＜0.001;RSV had the highest positive rate among children in spring,at 13.17％,and there was statistical significance in the positive rate among children in different seasons,x-=69.655,P＜0.001.There were 28 cases with co-infection of two or more viruses in the children.Conclusions The respiratory tract infections virus spectrum of children in Zibo City has differences in terms of season and age group.Clinicians should combine the epidemiological characteristics of respiratory infection virus in this area to prevent and control respiratory tract infections in children.
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