Research progress on molecular mechanism of hematopoietic stem cellular aging
Hematopoietic stem cells can meet the needs of the body for various types of blood cells.With age,hematopoiet-ic stem cells gradually age,their function decreases,and their quantity changes.Biological aging originates from stem cell aging.With the aging of the population,age-related diseases are increasingly receiving attention.This study discusses the molecular aging mechanism of hematopoietic stem cells from both internal and external factors of cells.Using the key-words"hematopoietic stem cells"and"aging",we searched for relevant literature on CNKI and PubMed from January 1,2018 to July 31,2023.Inclusion criteria:Research on senescence-related pathways of hematopoietic stem cells;Research on aging and DNA damage of hematopoietic stem cells;Research on aging and metabolism of hematopoietic stem cells;Research on aging and epigenetics of hematopoietic stem cells;Research on aging and environment of hematopoietic stem cells.Exclusion criteria:Documents that are older and of poorer quality.Finally,52 articles were included for analysis.The results indicate that the molecular mechanism of hematopoietic stem cell aging involves both intracellular and extracel-lular factors,among which factors such as DNA damage,metabolism,epigenetics,and environment are involved in the aging process of hematopoietic stem cells.Further research on the aging related mechanisms of hematopoietic stem cells is expected to discover more effective new targets for delaying or even reversing the aging process of hematopoietic stem cells.
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