Effect of integrative Chinese and Western medicine on improving clinical symptoms in patients with rheumatoid arthritis
Objective To investigate the therapeutic effect of integrated Chinese and western medicine in patients with rheu-matoid arthritis(RA).Methods From July 1,2021 to June 30,2022,62 RA patients from the Rheumatology and Im-munology Department of Nanyang First People's Hospital in Henan Province were selected and divided into two groups ac-cording to the random number table method:a conventional treatment group(n=31)and an integrated traditional Chinese and Western medicine treatment group(n=31).The conventional treatment group received Western medical treatment,while the integrated traditional Chinese and Western medicine treatment group received dialectical typing treatment based on the conventional treatment group.Clinical symptom indicators,laboratory test indicators,immune function indicators,treatment efficiency,and incidence of adverse reactions were compared between the two groups.Results There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The treatment efficiency of the integrated traditional Chinese and Western medicine treatment group was 96.77％,which was better than the 74.19％of the conventional treatment group,with a statistically significant difference,x4=6.369,P＜0.05.After treatment,the clinical symptom indicators of the integrated traditional Chinese and Western medicine treatment group[joint pain score:(1.13±0.50)points,joint tenderness score:(1.23±0.92)points,joint mobility score:(1.16±0.52)points,joint swelling score:(1.29±0.69)points,20-meter walking time:(18.13±4.24)seconds,morning stiffness time:(32.28±3.74)minutes,hand grip strength:(82.94±4.69)mmHg]were better than those of the conventional treat-ment group[joint pain score:(1.87±0.56)points,joint tenderness score:(2.16±0.64)points,joint mobility score:(1.90±0.65)points,joint swelling score:(2.32±1.22)points,20-meter walking time:(20.86±5.36)seconds,morning stiffness time:(39.68±4.41)minutes,hand grip strength:(74.81±4.26)mmHg],with statistically signifi-cant differences,F values were 53.299,38.746,45.127,34.681,12.259,133.592,173.958,all P＜0.05.After treat-ment,the clinical laboratory indicators of the integrated traditional Chinese and Western medicine treatment group[tumor necrosis factor-α(TNF-α):(12.41±3.62)pg/mL,interleukin-6(IL-6):(1.13±0.59)ng/L,interleukin-17(IL-17):(18.52±4.68)pg/L,C-reactive protein:(22.15±1.56)mg/L,erythrocyte sedimentation rate:(14.85±2.31)mm/h,rheumatoid factor:(244.34±21.48)IU/mL,anti-cyclic citrullinated peptide antibody:(3.37±1.32)RU/mL]were better than those of the conventional treatment group[TNF-α:(15.95±3.71)pg/mL,IL-6:(1.86±0.59)ng/L,IL-17:(25.68±4.52)μg/L,C-reactive protein:(24.83±1.84)mg/L,erythrocyte sedimentation rate:(18.84±2.54)mm/h,rheumatoid factor:(296.58±25.67)IU/mL,anti-cyclic citrullinated peptide antibody:(5.24±1.79)RU/mL],with statistically significant differences,F values were 37.855,74.685,106.373,139.695,139.695,91.359,286.819,46.762,all P＜0.05.After treatment,the immune function indicators of the integrated traditional Chinese and Western medicine treatment group[immunoglobulin G(IgG):(16.38±4.24)g/L,complement C3:(0.68±0.37)g/L,comple-ment C4:(18.26±2.15)g/L,helper T cell 17(Th17):(1.57±0.58)％,regulatory T cell(Treg):(1.58±0.26)％,and the ratio of Th17/Treg was(0.83±0.29)％.The Visual Analog Scale(VAS)score was(4.26±0.77)points,the Sharp scale score was(3.35±1.23)points,and the Health Assessment Questionnaire(HAQ)score was(0.35±0.49)points.These were all better than the conventional treatment group,with IgG levels at(10.52±2.93)g/L,Complement C3 at(1.53±0.41)g/L,Complement C4 at(22.18±2.16)g/L,Th17 at(2.46±0.67)％,Treg at(1.02±0.21)％,and the ratio of Th17/Treg at(1.46±0.32)％.The VAS score was(4.84±0.82)points,the Sharp score was(5.39± 1.71)points,and the HAQ score was(0.65±0.49)points.The differences were statistically significant,with F values of 127.747,205.011,169.920,70.203,134.148,174.532,11.182,44.285,and 5.616,all P＜0.05.Conclusion The use of integrative medicine in the treatment of RA patients can improve the therapeutic effect,enhance clinical symptoms and in-flammatory responses,and enhance immune function with high safety,which is worthy of promotion and application.
integrated therapy of Chinese and Western medicinerheumatoid arthritisclinical symptom indeximmune function indextherapeutic effectiveness
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