摘要
目的 以老年人为研究对象,探讨血红蛋白浓度与代谢综合征(MetS)及其组分患病的关系,进而为老年人MetS的防治提供科学依据.方法 选择2021-01-01-12-31在青岛市某区社区卫生服务中心进行健康体检的≥65岁老年人作为研究对象,共纳入35 966名老年人,按照血红蛋白浓度的三分位数分为T1(＜132 g/L)、T2(132～144 g/L)和T3(≥144 g/L)3个组,采用logistic回归分析血红蛋白对MetS及其组分患病的影响.结果 MetS患者18 202例,患病率为 50.60％;MetS 组的腰围(t=71.23,P＜0.001)、收缩压(t=50.66,P＜0.001)、舒张压(t=29.51,P＜0.001)、三酰甘油(t=68.01,P＜0.001)、空腹血糖(t=63.17,P＜0.001)、血红蛋白(t=24.12,P＜0.001)水平高于非 MetS 组,但 MetS组的高密度脂蛋白胆固醇含量低于非MetS组(t=27.19,P＜0.001),差异均有统计学意义.logistic回归分析结果表明,在控制混杂因素后,血红蛋白T2组患MetS(95％CI:1.80～2.01)、腹型肥胖(95％CI:1.52～1.73)、高血压(95％CI:1.31～1.51)、高血糖(95％CI:1.47～1.64)和血脂异常(95％CI:1.28～1.44)的风险分别是T1组的 1.91、1.62、1.41、1.44 和 1.36 倍,均 P＜0.001;血红蛋白 T3 组患 MetS(95％CI:2.09～2.34)、腹型肥胖(95％CI:1.84～2.12)、高血压(95％CI:1.53～1.77)、高血糖(95％CI:1.56～1.74)和血脂异常(95％CI:1.33～1.49)的风险分别是 T1组的 2.21、1.98、1.65、1.64和1.41倍,均P＜0.001.结论 血红蛋白浓度与MetS及其组分患病相关,血红蛋白水平可以作为老年人MetS及其组分患病的临床预测指标.
Abstract
Objective To explore the relationship between hemoglobin concentration and metabolic syndrome(MetS)and its components in elderly individuals,and to provide a scientific basis for the prevention and treatment of MetS in the elderly.Methods A total of 35 966 elderly people aged ≥65 who underwent health examinations at a community health service center in a certain district of Qingdao from January 1 to December 31,2021 were selected as the research subjects.Ac-cording to the third percentile of hemoglobin concentration,they were divided into three groups:T1(＜132 g/L),T2(132-144 g/L),and T3(≥144 g/L).Logistic regression analysis was used to investigate the impact of hemoglobin on MetS and its components.Results There were 18 202 MetS patients,with a prevalence rate of 50.60％.The waist circ-umference(t=71.23,P＜0.001),systolic blood pressure(t=50.66,P＜0.001),diastolic blood pressure(t=29.51,P＜0.001),triglycerides(t=68.01,P＜0.001),fasting blood glucose(t=63.17,P＜0.001),and hemoglobin(t=24.12,P＜0.001)levels in the MetS group were higher than those in the non MetS group,but the high-density lipopro-tein cholesterol content in the MetS group was lower than that in the non MetS group(t=27.19,P＜0.001),and the differences were statistically significant.The results of logistic regression analysis showed that after controlling for confounding factors,the risk of MetS(95％CI:1.80-2.01),abdominal obesity(95％CI:1.52-1.73),hypertension(95％CI:1.31-1.51),hyperglycemia(95％CI:1.47-1.64),and dyslipidemia(95％CI:1.28-1.44)in the hemoglo-bin T2 group was 1.91,1.62,1.41,1.44,and 1.36 times higher than that in the T1 group,respectively,with all P＜0.001.The risk of MetS(95％CI:2.09-2.34),abdominal obesity(95％CI:1.84-2.12),hypertension(95％CI:1.53-1.77),hyperglycemia(95％CI:1.56-1.74),and dyslipidemia(95％CI:1.33-1.49)in the T3 group was 2.21,1.98,1.65,1.64,and 1.41 times higher than that in the T1 group,respectively,with all P＜0.001.Conclusion Hemo-globin is associated with MetS and its components,and hemoglobin levels can serve as a clinical predictive indicator for MetS and its components in the elderly.
基金项目
青岛市科技惠民示范引导专项(21-1-4-rkjk-1-nsh)
青岛市医疗卫生优秀人才培养项目()
NETL
NSTL
万方数据