A study on the correlation between the composition of urinary system stones and abnormal urinary metabolism and drinking water quality in the east of Henan province
Objective Through the method of overall random sampling,a questionnaire survey was conducted on permanent residents in the eastern part of Henan Province,to investigate their stone disease status,urine metabolism status,and drinking water source.The correlation between urinary system stone components,abnormal urine metabolism,and drinking water quality in the eastern part of Henan Province was analyzed.Methods A total of 1 200 permanent residents in the eastern Henan region were selected from October 1,2020 to October 1,2022 as the research subjects.The incidence of uri-nary system stones was statistically analyzed through a questionnaire survey,with 572 patients with recurrent urological stones(≥2 times)forming Group A,428 patients with a single episode of urological stones forming Group B,and 200 res-idents without stones forming Group C.General and clinical data of the three groups were collected,and risk factors that can lead to recurrent urinary system stones were summarized through statistical univariate analysis and logistic multiple regression analysis;The composition of stones,urine metabolism,and drinking water quality were analyzed,and their correlation was verified through Spearman correlation coefficient.Results Age ≥40 years old(95％CI:1.266-8.871,P=0.009),family history of hereditary diseases(95％CI:1.272-7.933,P=0.023),body mass index(BMI)≥25 kg/m2(95％CI:1.241-8.926,P=0.027),daily fat intake＞60 g/L(95％CI:1.175-7.886,P=0.016),daily calcium intake＞1 200 mg/d(95％CI:1.365-5.926,P=0.015),frequency of seafood consumption＞3 times/week(95％CI:1.288-5.879,P=0.023)The frequency of consuming pickled products＞3 times per week(95％CI:1.125-5.836,P=0.024),water consumption＜2 000 ml/d(95％CI:1.334-7.955,P=0.015),drinking mountain spring water(95％CI:1.285-8.936,P=0.011),and abnormal urine metabolism(95％CI:1.445-7.971,P=0.007)are risk factors for the occurrence or recurrence of urinary system stones;The main components of stones are uric acid stones at 37.40％(374/1 000)and calcium oxalate stones at 42.10％(421/1 000).According to Spearman correlation coefficient test,urine output,potassi-um,sodium,phosphorus,and pH value are negatively correlated with uric acid stones,while calcium and uric acid values are positively correlated with uric acid stones(r=-0.112,-0.125,-0.152,-0.154,-0.133,0.262,0.253,P＜0.05);Urinary output,potassium,pH,and uric acid levels are negatively correlated with calcium oxalate stones,while uri-nary calcium,sodium,and urine output are positively correlated with calcium oxalate stones(r=-0.124,-0.131,-0.126,-0.141,0.255,0.265,0.254,P＜0.05);The turbidity of drinking water is positively correlated with uric acid stones,while the hardness,TDS,and pH of drinking water are negatively correlated with uric acid stones(r=0.235,0.221,-0.157,-0.162,P＜0.05);The turbidity,hardness,TDS,and pH of drinking water are positively correlated with calcium oxalate stones(r=0.241,0.254,0.236,0.249,P＜0.05).Conclusions In addition to uncontrollable factors such as age and family history,obesity,poor personal diet or drinking habits can all lead to recurrent attacks of urinary system stones.The composition of stones in different patients is related to urinary metabolic function and drinking water quality.
urinary system calculistone compositionurine metabolic functiondrinking water qualitycorrelation analysis
NETL
NSTL
万方数据
