Exploration of the application value of ulinastatin in patients with multiple trauma and infection
Objective To explore the effects of ulinastatin on inflammatory state,immune function and coagulation indices in patients with multiple injuries combined with infection.Methods A total of 84 patients with multiple injuries combined with infection admitted to Zhengzhou First People's Hospital from May 8,2020 to April 20,2023 were selected as the study objects,and were divided into control group and combination group according to different treatment methods.The two groups were given symptomatic basic treatment.The control group(n=42)was treated with Xuebijing,while the combined group(n=42)was treated with ulinastatin on the basis of the control group.Univariate co-variance analysis was used to compare the inflammatory status,immune function,and coagulation indices between the two groups of pa-tients.Results After 1 week of treatment,the level of tumor necrosis factor α(TNF-α)was(31.68±4.76)ng/L,which was lower than that of control group(38.91±6.07)ng/L,and the level of interleukin-6(IL-6)was(36.08±8.62)ng/L,lower than the control group's(44.75±10.15)ng/L,the level of procalcitonin(PCT)was(1.03±0.29)mg/ml,lower than the control group's(1.54±0.36)mg/ml,the difference was statistically significant,with F-values of 1 528.423,250.711 and 445.479,all P＜0.001.After 1 week of treatment,the level of CD3+in the combination group was(60.08±9.73)％,higher than that in the control group's(49.63±7.42)％,the level of CD4+was(44.91±8.06)％,higher than that in the control group's(37.96±6.51)％,and the CD4+/CD8+level was 1.58±0.81,higher than the control group's 1.29±0.65,the differences were statistically significant,with F-values of 462.671,670.528,and 20.630,all P＜0.001.After 1 week of treatment,the fibrinogen(FIB)level in the combination group was(3.31±0.82)g/L,higher than that in the control group's(2.58±0.67)g/L,and the prothrombin time(PT)level was(12.16±2.84)s,lower than that in the control group's(16.08±3.51)s,the activated partial thrombin time(APTT)was(34.23±3.51)s,lower than that of the control group's(37.48±3.72)s,and the difference was statistically significant,with F-values of 1 172.372,127.816 and 475.761,all P＜0.001.Conclusion Ulinastatin can regulate coagulation index,improve inflammatory state and regulate immune function in patients with multiple injuries combined with infection.
ulinastatinmultiple injuriesinflammatory factorsimmunitycoagulation function
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