小鼠肠缺血再灌注损伤模型的构建与应用
Construction and application of a mice model of intestinal ischemia reperfusion injury
刘婷婷 1田丰 2贾中芝2
作者信息
- 1. 大连医科大学研究生院,辽宁 大连,116044;南京医科大学附属常州市第二人民医院介入血管科,江苏常州,213003
- 2. 南京医科大学附属常州市第二人民医院介入血管科,江苏常州,213003
- 折叠
摘要
肠缺血再灌注损伤(IRI)是临床上常见的急危重症,发病率和死亡率均较高.目前对肠IRI的基础研究得到广泛关注,而成功地构建肠IRI动物模型是开展基础研究的基础,夹闭肠系膜上动脉的肠IRI动物模型应用最为广泛.本文详细阐述了夹闭肠系膜上动脉的小鼠肠IRI模型的构建过程及注意事项,将有助于提高小鼠肠IRI模型构建的成功率,从而助推肠IRI的动物体内研究.
Abstract
Intestinal ischemia reperfusion injury(IRI)is a common clinical emergency with high morbidity and mortality.Mechanistic studies of intestinal IRI have received extensive attention,and the successful construction of an animal model of intestinal IRI is the basis for basic research.The rodent animal model of clamped superior mesenteric artery is a widely used animal model of intestinal IRI.This article describes in detail the process of constructing a mice model of intestinal IRI by clamping the superior mesenteric artery and the precautions to be taken.It will help to regulate the construction of the mice model of intestinal IRI and improve the success of the model construction,thus contributing to the basic research of intestinal IRI.
关键词
小鼠/肠/缺血再灌注损伤/模型Key words
mouse/intestinal/ischemia reperfusion injury/model引用本文复制引用
基金项目
中国博士后科学基金(2023M730371)
南京医科大学常州医学中心项目(CMCC202206)
南京医科大学常州医学中心项目(CMCB202304)
出版年
2024
NETL
NSTL
万方数据