术前营养风险指数与进展期胃癌术后患者预后的相关研究分析
Analysis of the correlation between preoperative nutritional risk index and postoperative prognosis of patients with advanced gastric cancer
牛闻宇 1康金科 1支永发 1张义 1马明杰1
作者信息
- 1. 青海红十字医院胃肠外科,青海西宁,810000
- 折叠
摘要
目的 探讨营养风险指数(NRI)与进展期胃癌术后患者预后的关系.方法 回顾性分析 2009 年 1 月—2022 年 12 月在青海红十字医院胃肠外科经病理确诊为胃癌并行根治术住院患者 213 例的临床资料.根据患者术前 1 周内的检查结果评估患者营养状况并计算NRI值.NRI是通过人体血清白蛋白(Alb,g/L)、现有体重(cBW,kg)与平日体重(uBW,kg)比值的计算公式(NRI=1.519×Alb+41.7 cBW/uBW)得出.采用Kaplan-Meier生存曲线和Cox比例风险模型研究NRI对胃癌患者术后预后的影响.结果 中、重度营养不良患者行胃癌根治术后 5 年生存率较轻度营养不良及正常营养状况患者低(45.3%vs.64.0%,P=0.024).术前NRI是胃癌患者术后无进展生存期(PFS)的独立危险因素(P=0.041);术前NRI及血清白蛋白水平是胃癌患者术后总生存期(OS)的独立危险因素(P值分别为<0.001、= 0.01).结论 术前NRI对胃癌行根治术患者的预后有一定的预测作用,可作为一项便捷的指标对胃癌患者术前营养状况进行评估,并对其预后进行初步预测.
Abstract
Objective To explore the correlation between Nutritional Risk Index(NRI)and the post-operative prognosis of patients with advanced gastric cancer.Methods The clinical data of 213 patients with advanced gastric cancer who received gastrectomy from January 2009 to December 2022 in Qinghai Red Cross Hospital were analyzed retrospectively.The NRI was calculated with the results measured 1 week before surgery.NRI was calculated as(1.519×serum albumin,g/L)+(41.7×current/usual body weight,kg).The correlation between NRI and the post-operative prognosis of patients with advanced gastric cancer was analyzed with survival curves described by Kaplan-Meier method and the prognostic factors were identified with the Cox proportional hazard model.Results Moderate to severe malnourished patients had lower 5-yr OS(45.3%)compared with normal to mild group(64.0%)(P=0.024).Preoperative NRI may be one of the independent prognostic factors of PFS for patients with gastric cancer(P=0.041).Preoperative NRI and the level of serum albumin may be independent prognostic factors of OS for patients with gastric cancer(P<0.001,P=0.01,respectively).Conclusion Preoperative NRI may predict the post-operative prognosis of patients with advanced gastric cancer and is a significant predictor in evaluating the nutritional status of patients with gastric cancer.
关键词
营养风险指数/进展期胃癌/预后Key words
nutritional risk index/advanced gastric carcinoma/prognosis引用本文复制引用
基金项目
青海省医药卫生指导性课题(2022-wjzdx-95)
出版年
2024
NETL
NSTL
万方数据