术前系统性炎症评分对接受根治性手术治疗的结直肠癌患者远期预后的预测价值
Predictive value of preoperative systemic inflammation score for long-term prognosis of colorectal cancer patients treated with radical surgery
蒋文亮 1荀锋 1程少奇 1王宏刚 1夏勇2
作者信息
- 1. 南京医科大学附属泰州人民医院普通外科,江苏 泰州,225300
- 2. 高邮市人民医院普通外科,江苏 扬州,225600
- 折叠
摘要
目的 本研究旨在评估术前系统性炎症评分(SIG)对接受根治性手术治疗的结直肠癌(CRC)患者远期预后的预测价值.方法 纳入 2015 年 1 月—2018 年 6 月期间在南京医科大学附属泰州人民医院接受根治性结直肠癌手术治疗的 189 例患者.采用单因素和多因素Cox回归分析方法评估影响总生存期的因素,并绘制受试者工作特征(ROC)曲线分析SIG的预测价值.结果 SIG评分、中性粒细胞与淋巴细胞比值(NLR)分组及改良格拉预后评分(mGPS)均与结直肠癌患者预后相关,其中SIG的预测准确性最高.SIG评分越高,患者 5 年总生存率(OS)越低.结论 SIG可作为一种有价值的生物标志物,或有助于预测接受根治性手术治疗的结直肠癌患者的远期预后.
Abstract
Objective This study aimed to evaluate the predictive value of preoperative Systemic Inflammatory Grade(SIG)for long-term prognosis in colorectal cancer(CRC)patients undergoing curative surgery.Methods A total of 189 CRC patients who underwent curative surgery between January 2015 and June 2018 were included.Univariate and multivariate Cox regression analyses were performed to identify factors affecting overall survival(OS),and receiver operating characteristic(ROC)curve was conducted to evaluate the predictive value of SIG.Results SIG score,neutrophil-to-lymphocyte ratio(NLR)group and modified Glasgow Prognostic Score(mGPS)were all associated with prognosis in CRC patients,with SIG having the highest predictive accuracy.Patients with higher SIG scores had lower 5-year OS rates.Conclusion SIG can serve as a valuable biomarker to predict long-term prognosis in CRC patients undergoing curative surgery.
关键词
结直肠癌/系统性炎症评分/远期预后Key words
colorectal cancer/systemic inflammatory grade/long-term prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据