Bromadiolone exposure induced developmental toxicity in zebrafish embryos/larvae
To investigate the potential ecological toxicity of the second generation anticoagulant rodenticide bromadiolone,the developmental toxicity of bromadiolone on zebrafish embryos/larvae and its effect on the antioxidant system were studied.The results showed that the exposure to bromadiolone could lead to developmental toxicity such as death and deformity in zebrafish embryos/larvae.When the bromadiolone concentration was higher than 0.39 mg·L-1,the mortality and deformity rate of zebrafish embryos/larvae increased significantly.Exposure to bromadiolone also had a significant effect on the antioxidant system of zebrafish embryos/larvae.The activities of SOD and CAT and the contents of GSH and MDA increased significantly with the increase of bromadiolone exposure concentration,indicating that bromadiolone caused oxidative damage to zebrafish embryos/larvae,which led to the attenuation of other body functions and even death.In this paper,the developmental toxicity and oxidative damage of embryos/larvae caused by bromadiolone exposure were investigated and discussed,which provided a basis for further study on the developmental toxicity mechanism of bromadiolone on animals and its potential ecological hazards.
国家科技期刊平台
NSTL
万方数据
