多不饱和脂肪酸对钾通道的调控作用及机理
Role and Mechanism of Polyunsaturated Fatty Acids on Potassium Ion Channels
孙雨蕉 1常超 2吴振华 2张艺扉 3田裕涛3
作者信息
- 1. 天津大学医学工程与转化医学研究院,天津 300072
- 2. 天津大学胸科医院心脏外科重症监护室,天津 300051
- 3. 天津大学医学工程与转化医学研究院,天津 300072;天津市脑科学与神经工程重点实验室,天津 300072
- 折叠
摘要
多不饱和脂肪酸具有包括离子通道在内的众多作用靶点,通过作用于这些靶点,可以有效保护免疫系统、神经系统和心血管系统的功能,在一定程度上保护人体健康.电压门控钾离子通道家族KV7通道和大电导钙离子激活的钾离子通道(BKCa)广泛表达于机体的各类组织中,具有重要的生理或病理功能.本综述围绕KV7和BKCa通道,根据对已有报道的汇总,多不饱和脂肪酸可以增大KV7和BKca通道的电流幅值,其中对KV7通道电流的影响主要是改变其电压依赖特性和最大电导值,而对BKCa通道电流的影响主要是改变其孔道区域关闭态的构象.此外,多不饱和脂肪酸对KV7和BKCa通道功能的调节也会受到共表达的辅助亚基影响,但相关机制有待进一步阐明.深入理解多不饱和脂肪酸对KV7和BKCa通道调节作用效果和分子机制,有助于全面理解KV7和BKCa通道的生理意义,并为相关疾病诊疗策略研究提供新的前景.
Abstract
Polyunsaturated fatty acids(PUFAs)have diverse health-promoting effects,such as potentially protecting in immune,nervous,and cardiovascular systems by targeting a variety of sites,including most ion channels.Voltage-gated potassium channels of the KV7 family and large-conductance Ca2+-and voltage-activated K+(BKCa)channels are expressed in many tissues,therefore,their physiological importance is evident from the various disorders linked to dysfunctional KV7 channels and BKCa channels.Thus,it is extremely important to learn how potassium channels are regulated by PUFAs.The aim of this review is to provide an overview of the effects of PUFAs on KV7 channels and BKCa channels functions,as well as the mechanisms underlying these effects.In summarizing reported effects of PUFAs on KV7 and BKCa channels mediated currents,we generally conclude that PUFAs increase the current amplitude,meanwhile,differential molecular and biophysical mechanisms are associated with the current increase.In KV7 channels the currents increasement are associated with a shift in the voltage dependence of channel opening and increased maximum conductance in KV7 channels,while in BKCa channels,they are associated with destabilization the pore domain closed conformation.Furthermore,PUFA effects are influenced by auxiliary subunits of KV7 and BKCa channels,associate with channels in certain tissues.although findings are conflicting.A better understanding of how PUFAs regulate KV7 and BKCa channels may offer insight into their physiological regulation and may lead to new therapeutic strategies and approaches.
关键词
多不饱和脂肪酸/KV7通道/BKCa通道/脂类分子/通道门控Key words
polyunsaturated fatty acids/KV7 channels/BKCa channels/lipid molecule/gating mechanism引用本文复制引用
基金项目
国家自然科学基金(32071103)
国家自然科学基金(32100726)
国家自然科学基金(82001420)
天津市教委科研计划(2022YGYB10)
出版年
2024
NETL
NSTL
维普
万方数据