循环肿瘤DNA的检测技术及在癌症诊疗中的应用价值
Circulating Tumor DNA Detection Technology and Its Application Value in Cancer Diagnosis and Treatment
张洁洁 1牛春艳 2董莲华 2杨怡 2李会杰 2杨靖亚3
作者信息
- 1. 上海海洋大学食品学院,上海 201306;中国计量科学研究院前沿中心,北京 100029
- 2. 中国计量科学研究院前沿中心,北京 100029
- 3. 上海海洋大学食品学院,上海 201306
- 折叠
摘要
循环肿瘤DNA(ctDNA)来源于肿瘤,能很好地反映肿瘤的基因信息,并且会随着肿瘤的进展发生相应的改变.近年来,ctDNA独特的能力备受人们关注并被广泛研究,本文在总结ctDNA的来源、性质和样品处理的基础上,对ctDNA的检测技术及在癌症诊疗中的应用进行综述,阐述了ctDNA标准物质在二代测序中的作用及重要性,并指出ctDNA样品的收集、存储、定量检测以及数据分析等各个流程中建立统一标准及规范的迫切性.
Abstract
Circulating tumor DNA(ctDNA)comes from tumor,reflecting the genetic information of the tumor well,and will change with the progress of tumor.In recent years,the unique capabilities of ctDNA have attracted much attention and been widely studied.In this paper,based on the summary of the source,properties and sample processing of ctDNA,its detection technology and application in cancer diagnosis and treatment are reviewed.The roles and importance of ctDNA reference material in second-generation sequencing are described.The urgency of establishing uniform standards and specifications of ctDNA in various processes,such as samples collection,storage,quantitative testing and data analysis,has been pointed out.
关键词
循环肿瘤DNA/液体活检/检测技术/应用/生物标志物Key words
circulating tumor DNA/liquid biopsy/detection technique/application/biomarker引用本文复制引用
基金项目
中国计量科学研究院(AKYZD202202)
出版年
2024
NETL
NSTL
万方数据