摘要
生长分化因子 5(growth/differentiation factor-5,GDF-5)属于转化生长因子 β(transforming growth factor-β,TGF-β)家族,在骨、软骨、心脏、大脑、肾脏、骨骼肌和肌腱、肝脏以及脂肪等多个器官组织中表达.GDF-5与其受体BMPR-I/BMPR-Ⅱ结合,激活Smad1/5/8、PI3K/Akt、p38-MAPK等信号,发挥促进细胞增殖分化、减少氧化应激损伤、细胞凋亡和组织纤维化等生物学功能.目前针对GDF-5的研究多聚焦在骨、软骨与肌腱的生长和修复等方面,而在其他器官中的生物学作用鲜有报道.因此,本文通过梳理和总结近年来GDF-5与代谢性疾病的研究进展,为GDF-5在改善代谢性疾病防治提供新的见解和理论依据.
Abstract
Growth/differentiation factor-5(GDF-5)belongs to transforming growth factor-β(TGF-β)family,which is expressed in bone,cartilage,heart,brain,kidney,skeletal muscle and tendon,liver,fat and other organs and tissues as well.GDF-5 binds to receptor BMPR-I/BMPR-Ⅱ and activates different signaling pathways such as smad1/5/8,PI3K/Akt,p38-MAPK.For a long time,numerous studies have shown that GDF-5 plays an important role in protecting joints.However,researchers have found GDF-5 also plays significant biological functions in other organs.For example,GDF-5 improves cardiac function by reducing oxidative stress and fibrosis in infarcted hearts.GDF-5 can also reduce oxidative stress in the brain and increase the number of neurons in effort to delay the progression of Alzheimer's disease and Parkinson's disease.It is a situation,research on GDF-5,at present,mainly focuses on the growth and repair of bone,cartilage and tendons,while there are few reports on its biological effects in other organs.Therefore,this article reviews and summarizes the research progress on GDF-5 and metabolic diseases in recent years in order to provide new insights and theoretical basis for the role of GDF-5 in improving metabolic diseases.
维普
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