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输血前检测技术的应用与展望

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精准输血对疾病治疗、急诊抢救意义重大。开展输血前多项标志物检测是保障精准治疗的关键,是降低输血风险的前提。输血前检测主要是指为保证输血安全、预防交叉感染,从而对血型、凝血、感染等进行检测。其常规检测指标包括血型、交叉配血、纤维蛋白原、病毒性肝炎、人类免疫缺陷病毒和梅毒等。传统的临床输血前检测技术以免疫分析为主。随着临床救治需求由院内向现场救治拓展,电化学传感技术、微流控技术、光谱技术等新技术也逐步发展用于输血前快速检测。基于此,本文综述了不同输血前检测技术的应用场景和优缺点,分析了系列新技术在输血前检测中的应用及未来发展趋势,为推动输血前检测乃至疾病标志物快速检测技术的发展提供参考。
Application and Prospect of Pre-transfusion Detection Technology
Blood transfusion accuracy is crucial for disease treatment and emergency rescue.Prior to a blood transfusion,it is essential to perform a number of tests to assure proper clinical treatment and reduce the risk of complications.Pre-transfusion testing refers primarily to the blood group,coagulation,and infection to assure transfusion safety and prevent cross-infection.Blood type,cross-matching blood,fibrinogen,viral hepatitis,human immunodeficiency virus,and syphilis are routine pre-transfusion tests.Immunoassay is the traditional clinical pretransfusion detection method.With the expansion of clinical treatment requirements from hospital to on-site treatment,new technologies,such as electrochemical sensing,microfluidics,and spectroscopy technology,are being developed gradually for rapid detection prior to blood transfusion.The development of technologies including colloidal gold immunity and biochips has facilitated the shift from large-scale laboratory equipment to portable testing for pre-transfusion screening.Further,the introduction of artificial intelligence technologies such as machine learning,biometric technology,and computer vision has contributed to the advancement of intelligent pre-transfusion testing.This article reviews the various application scenarios,benefits,and drawbacks of different pre-transfusion detection technologies,analyzes the application of a series of new technologies in pre-transfusion detection and its future development trend,and provides a reference for promoting the development of pre-transfusion detection and even rapid disease marker detection.

safety of blood transfusiondetection technologyportablechemical sensingpoint-of-care testing

孙金元、杨毅、罗文浩、张洪、罗阳

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重庆大学医学院智慧检验与分子医学中心,重庆 400030

重庆大学生物工程学院,重庆 400044

国家卫健委出生缺陷与生殖健康重点实验室,重庆 400020

山东大学第二医院检验医学中心,济南 250033

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输血安全 检测技术 便携式 化学传感 即时检测

国家杰出青年科学基金国家自然科学基金国家自然科学基金中国博士后科学基金中国博士后科学基金

821250228207238382202633BX202201942022M721937

2024

生物化学与生物物理进展
中国科学院生物物理研究所,中国生物物理学会

生物化学与生物物理进展

CSTPCD北大核心
影响因子:0.476
ISSN:1000-3282
年,卷(期):2024.51(3)
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