环状RNA参与鼻咽癌发生发展
Circular RNAs Involved in The Development of Nasopharyngeal Carcinoma
左思程 1王丹 2莫勇真 3刘宇航 2蔡姣迪 4郭灿 2熊芳 3陈国群4
作者信息
- 1. 长沙市第四医院病理科,长沙 410006;中南大学肿瘤研究所,国家卫健委癌变原理重点实验室,长沙 410078
- 2. 中南大学肿瘤研究所,国家卫健委癌变原理重点实验室,长沙 410078
- 3. 中南大学肿瘤研究所,国家卫健委癌变原理重点实验室,长沙 410078;中南大学湘雅医院耳鼻咽喉头颈外科,国家老年疾病临床医学研究中心,长沙 410078
- 4. 长沙市第四医院病理科,长沙 410006
- 折叠
摘要
环状RNA(circular RNA,circRNA)是一种具有共价闭环结构的非编码RNA(non-coding RNA,ncRNA),因其具有高稳定性、进化保守性和组织表达特异性的特点,越来越受到人们的关注.现有研究表明,circRNA参与恶性肿瘤等多种疾病的发生发展过程.鼻咽癌是一种起源于鼻咽上皮的恶性肿瘤,在中国华南和东南亚地区高发,发病与EB病毒(Epstein-Barr virus,EBV)感染密切相关.目前放疗和化疗是鼻咽癌治疗的主要手段,复发和远处转移是鼻咽癌患者死亡的主要原因.近年研究表明,circRNA作为基因表达调节因子,在鼻咽癌发生发展过程中发挥着重要的作用,影响着鼻咽癌的进展.本文主要综述了鼻咽癌中表达异常的circRNA,包括EB病毒编码的circRNA,在鼻咽癌发生发展中的研究现状,探讨了 circRNA作为鼻咽癌患者治疗的潜在靶点以及诊断和预后标志物的可能性.
Abstract
Circular RNAs(circRNAs)are a kind of non-coding RNA(ncRNA)with covalent closed-loop structure.They have attracted more and more attention because of their high stability,evolutionary conservatism,and tissue expression specificity.It has shown that circRNAs are involved in the development of a variety of diseases including malignant tumors recently.Nasopharyngeal carcinoma(NPC)is a malignant tumor that occurs in the nasopharynx and has a unique ethnic and geographical distribution in South China and Southeast Asia.Epstein-Barr virus(EBV)infection is closely related to the development of NPC.Radiotherapy and chemotherapy are the mainstays of treatment for NPC.But tumor recurrence or distant metastasis is the leading cause of death in patients with NPC.Several studies have shown that circRNAs,as gene expression regulators,play an important role in NPC and affect the progression of NPC.This review mainly summarized the research status of abnormally expressed circRNAs in NPC and EBV-encoded circRNAs.We also discussed the possibility of circRNAs as a therapeutic target,diagnostic and prognostic marker for NPC.
关键词
鼻咽癌/环状RNA/EB病毒/发病机制/生物标记物Key words
nasopharyngeal carcinoma(NPC)/circular RNAs(circRNAs)/Epstein-Barr virus(EBV)/pathogenesis/biomarker引用本文复制引用
基金项目
湖南省卫生健康委重点资助课题(202201043273)
长沙市自然科学基金(kq2202023)
出版年
2024
NETL
NSTL
万方数据